- Cardiovascular Disease $313.8 billion in direct costs to the U.S. in 2009
- Mental Disorders $169.5 billion in direct costs to the U.S. in 2009
- Diabetes $118.7 billion in direct costs to the U.S. in 2009
- Obesity $114.1 billion in direct costs to the U.S. in 2009
- Smoking $96.6 billion in direct costs to the U.S. in 2009
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