Wilson yielded four hits and struck out five, but rookie Danny Salazar pitched three-hit ball into the sixth inning in his fourth major league start for Cleveland, and his bullpen was impenetrable.
"We just didn't come through with those opportunities that we had," Wilson said. "That's the most frustrating part of the game, because we wouldn't have played so many innings if we scored one more run."
Mike Trout sat out his second straight game for Los Angeles, resting his tight right hamstring.
Wilson kept the Indians down until Santana led off the seventh with his 15th homer. Peter Bourjos lost his glove over the wall while trying to make the catch — so the Angels' center fielder scaled the wall, leaped over to get the glove back and climbed back onto the field.
Los Angeles' much-maligned bullpen retired 10 straight batters before Santana drew a two-out walk in the 13th and hustled to third on Gomes' single to left, but Cabrera flied out.
NOTES: Trout got hurt during Sunday's loss to Houston, forcing him to miss consecutive games for the first time in the past two seasons. The All-Star outfielder had skipped just one game all season before this series. ... Angels C Chris Iannetta snapped an 0-for-13 skid with a seventh-inning single, but Bourjos went hitless in six at-bats to drop to 0 for 18 since his return from a broken right wrist.
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