She made the jump to Sprint Cup this season and will battle Stenhouse for Rookie of the Year honors.
Starting out front in an unpredictable, 500-mile race doesn't guarantee any sort of result, but securing the pole will put her in the limelight for at least the rest of the week.
She also won the pole at Daytona for last year's Nationwide race.
This is considerably bigger.
The previous highest female qualifier in a Cup race was Janet Guthrie. She started ninth at Bristol and Talladega in 1977.
"It's obviously a history-making event that will last a long, long time," Guthrie said, praising Patrick's feat. "It's a different era, of course. Different times. I can't imagine what I would do with a spotter or somebody telling me how to drive. It's rather a different sport now. Back then, there was a much greater difference from the front of the field to the back."
Guthrie received a lukewarm reception from fellow drivers back then.
Patrick was much more welcomed, undoubtedly because of her background and popularity.
She's comfortable being in the spotlight, evidenced by her racing career, her television commercials and her sudden openness about her personal life.
"I think when pressure's on and when the spotlight's on, I feel like it ultimately ends up becoming some of my better moments and my better races and better results," Patrick said. "I just understand that if you put the hard work in before you go out there that you can have a little peace and a little peace of mind knowing that you've done everything you can and just let it happen."
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