The Cardinals also have uncertainty about left-hander Jaime Garcia, who was 7-7 with a 3.92 ERA last season but was limited to just 20 starts due to shoulder fatigue. He was lost for the rest of the postseason after injuring his left shoulder in Game 2 against the Nationals.
Wainwright, Jake Westbrook and Lance Lynn are expected to be in the rotation. Younger pitchers Joe Kelly, Trevor Rosenthal and Shelby Miller will compete for a spot.
"As we head into spring now there's certainly a void there, but there's also an opportunity," Matheny said. "We have to have some other guys step up."
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