Manning, Tuck and safety Antrel Rolle all said they knew the results of the other games by halftime, at least the Redskins' game.
"Our concern for the next three weeks is the New York Giants and that's all we can focus on," said Manning, who completed 22 of 35 for 259 yards.
The Giants could have folded against a team that had routed them the past two meetings. Instead, Wilson, who has been threatening all season to break a kickoff, fielded one at the 3, went up the middle and then veered toward the right corner of the end zone. He capped it with a somersault.
"That was huge," Rolle said. "That was huge. He has always been a fraction away from breaking it all year long and guys have been constantly pushing him to do it."
A fumble near midfield Jed Collins led to Manning's touchdown pass to Bennett and New York never trailed again.
Brees, who had never lost to the Giants and had eight TD passes and no interceptions in the last two games, finished 26 of 43 for 354 yards. New Orleans outgained New York 487-394, but mistakes were its undoing.
The Giants didn't cash in after Wilson's returns of 58 and 52 yards, but his 20-yarder late in the half after a short kickoff set up a 69-yard touchdown drive. Manning capped it with the fade route to Hixon.
Defensive tackle Linval Joseph returned Collins' miscue 16 yards to the Saints 35. A 16-yard pass to Hixon and a couple of penalties set up a 6-yard touchdown toss to Bennett for a 14-7 lead.
Brees took the Saints on drives of 81 and 67 yards in the second quarter, but each time the NFL's top red-zone offense settled for field goals of 32 and 25 yards by Garrett Hartley.
NOTES: Hixon had the old Giants single-season record for all-purposes yards at 303 in 2009. ...Wilson also set a single-season record for kickoff return yards with 1,301 yard....Brown has broken the Giants single-season record for interception return yards with 259 on seven interceptions. The old mark of 251 was set by Dick Lynch and Emlen Tunnell. ...Patrick Robinson had the Saints' other interception of Manning. Joseph Morgan has two catches for 106 yards for New Orleans.
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