The Giants (6-4) head into their bye with back-to-back losses and a lot of issues, especially on offense. The Giants turned it over four times in the second half.
COWBOYS 38, EAGLES 23
At Philadelphia, Dwayne Harris had a 78-yard punt return for a score, Brandon Carr returned an interception 47 yards for a TD and Tony Romo threw for two scores.
The Cowboys improved to 4-5, and are second in the NFC East, 1½ games behind the Giants.
The Eagles (3-6) lost Michael Vick to a concussion after consecutive bruising hits in the second quarter and have lost five straight games under coach Andy Reid for the first time in his 14 seasons.
Nick Foles filled in for Vick and briefly rallied the Eagles until the Cowboys started showing some touchdown versatility. Romo hit Dez Bryant on a 30-yard pass on the final play of the third quarter, and Harris and Carr scored their TDs in the fourth.
"Critical win for us," coach Jason Garrett said. "I thought the effort was there. I thought we were focused the whole game."
BUCCANEERS 34, CHARGERS 24
At Tampa, Fla., Josh Freeman threw two touchdown passes and the surging Buccaneers scored on a blocked punt and Leonard Johnson's 83-yard interception.
Freeman has thrown for 13 TDs with one interception in his past five games, helping the Bucs (5-4) win four times to climb over .500 following a 1-3 start.
Philip Rivers threw for 337 yards and three touchdowns for San Diego. He was intercepted twice in the fourth quarter to ruin any chance of the Chargers (4-5) coming from behind.
VIKINGS 34, LIONS 24
At Minneapolis, Adrian Peterson raced 61 yards for the game-sealing touchdown midway through the fourth quarter, padding his NFL rushing lead with 171 yards on 27 carries for Minnesota.
Peterson had 120 yards in the final 15 minutes, 10½ months after reconstructive surgery on his left knee, and has 1,128 yards on the ground. Christian Ponder bounced back from a rough game with 221 yards and two touchdowns on 24-for-32 passing for the Vikings (6-4).
Calvin Johnson had 207 yards on 12 catches, including a touchdown for the Lions (4-5), but Johnson's lost fumble near midfield on the previous possession put Vikings rookie Blair Walsh in position for his fourth field goal.
SEAHAWKS 28, JETS 7
At Seattle, Russell Wilson threw touchdowns of 38 yards to Golden Tate and 31 yards to Sidney Rice.
Wilson was harried for much of the day by the multiple looks from the Jets' defense. But the Seattle rookie responded with key throws, hitting Tate on the opening drive then connecting with Rice early in the fourth quarter to give Seattle (6-4) a two-score advantage. Tate added a TD pass on a reverse to Rice later in the fourth quarter.
Mark Sanchez struggled in his reunion with Seattle coach Pete Carroll, his former coach at USC. Sanchez threw a costly interception at the goal line in the first half then fumbled at the Seattle 32.
Muhammad Wilkerson's fumble return for a TD was the only score for New York (3-6).
Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL