As for the Indians, they dropped to 2-2 under interim manager Sandy Alomar Jr., who hopes to become Cleveland's permanent manager.
"It'd be great. It'd be awesome," Alomar said before the game. "I played here many years. I'm very proud of this organization. They have treated me great. They brought me back. If it's the time, it's their choice. If it's the time, it's time. if not, there will be some other time."
Alomar took over last week when the Indians fired Manny Acta with six games left. Alomar, who served Acta's bench coach this season, will likely interview with the Indians by the end of the week. He and former Boston Red Sox manager Terry Francona are the only candidates confirmed so far by the club, which has tentatively set up a meeting with Francona on Friday.
NOTES: Pierzynski has 77 RBIs, matching a career-high. ... With his performance, Santiago helped Chicago's set a club record for strikeouts in a season. The White Sox have fanned 1,225 batters, five more than in 2011. ... Dunn has 220 strikeouts, three away from the major league record set by Mark Reynolds with Arizona in 2009. ... Santiago's 10 strikeouts were the most by a Chicago rookie since Jason Bere, who struck out 12 Angels on Sept. 20, 19093.