Manuel retired after throwing his second touchdown pass, a 19-yard throw to Kenny Shaw, in the final minute of the third period that gave the Seminoles a 45-0 lead. He completed 15 of 24 passes for 172 yards and two scores.
The Seminoles kept the Demon Deacons pinned down deep in their own territory throughout the first half. Wake Forest first five offensive possessions started inside its 20, including two at the five.
It was sixth time Florida State has shut out Wake Forest., which suffered its last shutout two years ago in Tallahassee, 31-0.
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