The Rams had no answers for Luck.
Four plays after this year's top draft pick converted a third-and-3 with the 12-yard pass to Hilton, Luck hooked up with Austin Collie in the front corner of the end zone for a 23-yard score to make it 14-0.
On Luck's fourth series, he took the Colts on a methodical 13-play, 80-yard drive. Delone Carter ended the drive with a 1-yard run to make it 21-3, and Indy closed it out with two second-half touchdowns and Pat McAfee's 31-yard field goal — even if the Colts know things are about to get much tougher for the rookie.
"I'm sure he's going to have some bumpy roads from here on out. Every game is not going to be like this," veteran receiver Reggie Wayne said. "As players, we understand that. Us being able to overcome those bumpy roads and keep it moving makes the next time out there better."
NOTES: The Colts lost four players to injury. Linebacker Pat Angerer (foot), starting offensive guard Mike McGlynn (sprained ankle), linebacker Scott Lutrus (sprained knee), and Carter (ribs) all left the game early and did not return. ... St. Louis played without receiver Danario Alexander (hamstring) and defensive tackle Trevor Laws (leg). ... The Rams ran 32 times for 116 yards, a 3.6-yard average. Isaiah Pead had 10 carries for 33 yards.
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