The White Sox moved farther and farther away from Humber as he approached history, leaving him alone as he sat on the bench in the Safeco Field visitors' dugout.
Justin Smoak struck out swinging to start the eighth. Kyle Seager lofted a fly to left that looked momentarily like it had a chance to land, but was caught by Dayan Viciedo. Jesus Montero followed with an easy ground ball to second base, sending the perfect game to the ninth.
Paul Konerko hit his second home run of the season and No. 398 for his career in the second. He also had a run-scoring single in the third.
Mariners starter Blake Beavan (1-2) allowed three runs and seven hits in six innings.
Humber becomes the latest one-time Mets pitcher who went on to throw a no-hitter elsewhere, a group that includes Nolan Ryan, Tom Seaver, Gooden and David Cone. New York has never had a no-hitter in its 51-year history. The only other team without one is San Diego, which began play in 1969.
NOTES: There were three no-hitters last year: Francisco Liriano of Minnesota, Justin Verlander of Detroit and Ervin Santana of the Los Angeles Angels. ... Seattle reliever Hisashi Iwakuma made his major league debut Friday night, becoming the last player on an Opening Day roster who was not hurt or optioned to the minor leagues to do so. . Rios came into Saturday with an eight-game hitting streak.
Associated Press Writer Manuel Valdes in Seattle contributed.
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