The biggest change, of course, is not seeing No. 18 around town.
Two days after Manning's release, the Colts cut other veterans including defensive captains Gary Brackett and Melvin Bullitt, Pro Bowl tight end Dallas Clark and running back Joseph Addai. Longtime center Jeff Saturday, receiver Pierre Garcon and backup tight end Jacob Tamme all left in free agency.
Now, the Colts are looking to start fresh.
"Barring any unforeseen problem we're pretty sure what direction we want to go. Barring any unforeseen event, we know what we're doing," Grigson said.