ST. JOHN'S (3) vs. Oklahoma (6) — The Red Storm are road-tested and will disappoint the Sooners faithful by finally making it out of the second round, winning on an opponent's home court for the first time in three NCAA tries.
DUKE (2) vs. Middle Tennessee (10) — Elizabeth Williams shows why she is one of the best freshmen in the country, asserting herself against Middle Tennessee.
STANFORD (1) vs. Purdue (4) — Nnemkadi Ogwumike has raised her game over the last month, even hitting 3-pointers in the Pac-12 tournament. She'll carry the Cardinal to the regional finals.
ST. JOHN'S (3) vs. Duke (2) — Great matchup at the point guard spot with Nadirah McKenith and Chelsea Gray. Duke really will miss Richa Jackson, who was lost for the season with an ACL injury. Shenneika Smith hit the big shot to beat UConn, she'll do it again to knock off the Blue Devils.
STANFORD (1) vs. St. John's (3) — President Obama has the Red Storm making the Final Four. The Red Storm won't be intimidated having already played Baylor, Notre Dame and UConn this season. They just don't match up well enough to stop the Ogwumike sisters.
DES MOINES REGIONAL
BAYLOR (1) vs. UC Santa Barbara (16) — First year UCSB coach Carlene Mitchell learned a thing or two about defense under Rutgers coach C. Vivian Stringer. Stopping Brittney Griner is too tall an order. Can the 6-foot-8 phenom get a triple double in limited action?
OHIO STATE (8) vs. Florida (9) — Jim Foster feels his Buckeyes were snubbed in the seeding. Talented guards Samantha Prahalis and Tayler Hill will be way too much for the Gators.
FRESNO STATE (12) vs. Georgetown (5) — Sugar Rodgers can flat out score. Unfortunately the Hoyas have been struggling to find consistency on offense besides her. The WAC champs have become one of the best mid-majors out West, thanks to the Bulldogs' uptempo pace and proficient 3-point shooting.
GEORGIA TECH (4) vs. Sacred Heart (13) — The Yellow Jackets came within a few minutes of winning the ACC championship. Senior Sasha Goodlett will be the difference for them in the opening round.
NEBRASKA (6) vs. Kansas (11) — The Cornhuskers made the most of their move to the Big Ten by losing in the conference tournament title game to Purdue. They'll have more than enough to beat old Big 12 rival Kansas.
DELAWARE (3) vs. Arkansas-Little Rock (14) — Elena Delle Donne will get her first taste of the NCAA tournament and carry the Blue Hens to their first win.
DEPAUL (7) vs. BYU (10) — The Blue Demons are in the tournament for the 10th straight season. This might be the best game of the first round as the Lady Cougars play tremendous defense. Anna Martin will carry DePaul to the second round.
TENNESSEE (2) vs. Tennessee Martin (15) — The last time the Skyhawks beat the Lady Vols, Pat Summitt was their star player. Summitt won't fall to her alma mater.
BAYLOR (1) vs. Ohio State (8) — The Buckeyes backcourt is good enough to hang with the top team in the nation. They don't, however, have an answer for Brittney Griner.
GEORGIA TECH (4) vs. Fresno State (12) — The Yellow Jackets will end the Bulldogs' run.
DELAWARE (3) vs. Nebraska (6) — The Cornhuskers have a young emerging star in Jordan Hooper, who had 14 double-doubles this season. They just don't have an answer on defense to stop Delle Donne.
TENNESSEE (2) vs. DePaul (7) — These two teams met on Dec. 11 in the Maggie Dixon Classic at Madison Square Garden and the Lady Vols won by 23 points. The Blue Demons had star Keisha Hampton for that game. She's out for the year with a knee injury.
BAYLOR (1) vs. Georgia Tech (4) — Brittney Griner will get a lot of help from her supporting cast, including star guard Odyssey Sims as the Lady Bears' march to national championship continues.