UConn was trailing 36-33 early in the second half when the pair scored 10 points during a 10-1 run. Mosqueda-Lewis had a floater and a jump shot. Hartley finished it off with the last six points, the final two coming after she stole the ball at midcourt and then made an acrobatic layup.
Notre Dame closed to 46-43 with 8:46 left on Kayla McBride's 3-pointer, but couldn't complete the comeback.
Mosqueda-Lewis and Hartley hit back-to-back baskets and UConn held Notre Dame without a field goal for 5½ minutes after Skylar Diggins' lay-in made it 50-45 with 7:05 left. Diggins finally ended the drought with 1:35 remaining, but UConn hit its free throws down the stretch to seal the win.
Diggins scored 16 points for Notre Dame (30-3).
The Huskies led 27-17 before Notre Dame closed the first half on a 13-4 burst. Kaila Turner's 3-pointer with a second left made it 31-30 at the break.
It's the first time all season that the Irish trailed a Big East opponent at the half.
Notre Dame kept the run going, scoring six of the first eight points of the second half to take a 36-33 lead on Devereaux Peters' layup. Then Hartley and Mosqueda-Lewis took over.
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