Britain's index was up just 0.3 percent after Moody's stripped the country late Friday of its triple-A credit rating.
Among other stocks making big moves:
— Drugmaker Affymax plunged $14.10, or 85 percent, to $2.42 after the company recalled its anemia drug following severe allergic reactions and the deaths of some kidney dialysis patients.
—Mead Johnson fell $3.64, or 4.6 percent, to $75.32 after the company said that a new regulation in Hong Kong could affect the company's sales there as well as in mainland China.
— Barnes & Noble rose $1.55, or 12 percent, to $15.06 after founder and chairman Leonard Riggio told the bookseller he is going to try to buy the company's retail business.
— Hertz advanced 31 cents, or 1.7 percent, to $19.04, despite posting a fourth-quarter loss, after the rental car company said that pricing improved, volume rose and it cut costs.
AP Business Writers Christina Rexrode and Matthew Craft contributed to the report.
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