The buy, which cost $1.1 million, targets Ohio Democrat Rep. Betty Sutton. The ad portrays Sutton as former House Speaker Nancy Pelosi's "puppet."
"She helped Pelosi pass Obamacare that cut $700 billion from Medicare," the ad says. "Sutton voted with Pelosi 99 percent of the time and counting."
Sutton, who is running for her fourth term in the Cleveland district, is neck-in-neck with freshman Republican Rep. Jim Renacci, who has outraised her by more than $500,000.
Experts expect millions more in congressional race ad buys in upcoming weeks.
"This is the time of year, when outside groups step up their advertising," says campaign finance expert Anthony Corrado. "This is when the electorate is beginning to focus on the race. This is when it matters."
Corrado says while they repetitious ads irritate many, they have enormous power to influence the electorate.
"These ads are more effective than people want to believe they are," Corrado says. "It is still the case that in some of these races, one ad can change the outcome of the race."
Lauren Fox is a political reporter for U.S. News and World Report. She can be reached at firstname.lastname@example.org or you can follow her on twitter @foxreports.