Price thinks Heller is vulnerable as "part of a block of votes in Congress that just want to undermine the president."
Heller defeated Democrat Jill Derby in both 2006 and 2008 — the first time after barely surviving a three-way GOP primary that included Nevada First Lady Dawn Gibbons and Sharron Angle, the former assemblywoman whose conservative views backed by the tea party won her the nomination on Tuesday to face Reid in November.
"Jill Derby came close. Sharron Angle came close," Price said. "I'm hoping to go after all those people who have voted against Heller previously."
Price, who will have to overcome a huge fundraising disadvantage, thanked her supporters with an e-mail on Wednesday asking for their continued support.
"Now I have a boatload of work to do. Don't go away, I need you," she wrote.
Berkley is expected to cruise past Kenneth Wegner, the same Republican she beat the last two times.
"She's in a district that if there is any anti-incumbent feeling it would be minimal," Raggio said.