Strep B Seems to Trick Immune System

Finding could lead to better treatment of sepsis, meningitis in newborns

Posted: July 13, 2009

MONDAY, July 13 (HealthDay News) -- A bacterial pathogen that causes sepsis and meningitis in newborns shuts down immune cell function to ensure its survival, a new study shows.

The findings about Group B Streptococcus (GBS) may help lead to new drugs for infectious diseases that affect about 3,500 newborns in the United States each year, said the researchers at the University of California, San Diego School of Medicine.

They found that GBS dupes the immune system into reducing production of antibiotic molecules.

"We have discovered that the bacteria have evolved to use a trick we call 'molecular mimicry.' Like a wolf in sheep's clothing, GBS can enter our body without activating the immune cells that are normally programmed to kill foreign invaders," Dr. Victor Nizet, a professor of pediatrics and pharmacy at UC San Diego, said in a news release.

The study appeared online July 13 in the Journal of Experimental Medicine.

In addition to causing infections in newborns, GBS is associated with serious infections in pregnant women, adult diabetics and the elderly.

More information

The MedlinePlus Medical Encyclopedia has more about GBS infections in newborns.

Start the discussion! Be the first to comment on this story.

Add Your Thoughts
About You

advertisement

U.S. News Rankings & Research

Best Hospitals

See the best hospitals, and the best children's hospitals, in specialties from cancer to urology.

Best Health Plans

U.S. News and NCQA review over 700 health insurance plans in the Best Health Plan rankings.

Best Nursing Homes

The Best Nursing Homes rankings feature data on 15,000-plus homes. Search for one near you.

Diseases & Conditions

Get information on preventing, treating, and managing diseases and conditions. Centers:

advertisement

Sponsored Poll

What factor do you think is responsible for the majority of teen-driving crashes?

View Results

advertisement

Subscribe

U.S. News Digital Weekly

A weekly insider's guide to politics and policy — in a multimedia, digital format. 52 issues for $19.95!

U.S. News & World Report

6 months of U.S. News & World Report's print edition for only $15. Save up to 67% off the cover price!